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KUMAUN UNIFOURVERSITY, NAINITAL, , SYLLABUS FOR FOUR SEMESTER (TWO YEAR) M.Sc. DEGREE, IN CHEMISTRY, , Effective from academic year 2017-18, , DISTRIBUTION OF DIFFERENT COURSES SEMESTER WISE, There shall be following components of the subjects in the I& IIIsemester courses, for each of the five papers., Theory, Ext., 75, Marks, , Int., 25, Marks, , Theory, Ext., 75, Marks, , Int., 25, Marks, , Theory, Ext., 75, Marks, , Int., 25, Marks, , Theory, Ext., 75, Marks, , Int., 25, Marks, , Theory, Ext., 75, Marks, , Int., 25, Marks, , Practical, Ext., 75, Marks, , There shall be following components of the subjects in the II semester course for, each of the four papers., Ext., 75, Marks, , Int., 25, Marks, , Ext., 75, Marks, , Int., 25, Marks, , Ext., 75, Marks, , Int., 25, Marks, , Ext., 75, Marks, , Int., 25, Marks, , Practical, 75, 25, Marks Marks, , 500, , There shall be following components of the subjects in the IVsemester course for, each of the two papers along with a Project work/dissertation, Ext., 75, Marks, , Int., 25, Marks, , Ext., 75, Marks, , Int., 25, Marks, , Practical, 75, 25, Marks Marks, , 300, , Page 1 of 48, , Int., 25, Marks, , Total, , 600

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Kumaun University Nainital, Department of Chemistry, Course Contents M.Sc. (2Year Degree), Effective from the Academic Year 2017-2018, Odd Semester Structure, Semester I, Paper I, Paper II, Paper III, Paper IV, , Inorganic Chemistry -1, Organic Chemistry - 1, Physical Chemistry - 1, Group Theory and Instrumentation Chemistry-1, , Paper V, , CHPG 101, CHPG 102, CHPG 103, CHPG 104, CHPG 105, , Practical, , CHPG 10P, , Inorganic/ Organic Chemistry Practical – 1, , Solid State Chemistry -3, SpectroscopicTechniques- 3, Chemistry for Biological System -3, Inter Disciplinary Topics in Chemistry-3, , Practical, , CHPG 301, CHPG 302, CHPG 303, CHPG 304, CHPG 305, CHPG 30P, , Semester II, Paper I, Paper II, Paper III, Paper IV, Practical, , CHPG 201, CHPG 202, CHPG 203, CHPG 204, CHPG 20P, , Inorganic Chemistry -2, Organic Chemistry - 2, Physical Chemistry - 2, Spectroscopic Techniques-2, Physical/ Organic Chemistry Practical – 2, , CHPG 40I, CHPG 40O, CHPG 40P, CHPG 40L, , Elective two papers in Inorganic Chemistry group, Elective two papers in Organic Chemistry group, Elective two papers in Physical Chemistry group, Laboratory course/ Project work, , Semester III, Paper I, Paper II, Paper III, Paper IV, Paper V, , a. Biology for Chemist (for Mathematics student) -1, b. Mathematics for Chemist (for Biology student) -1, , Photo Chemistry and Allied Chemistry-3, , Inorganic/ Physical Chemistry Practical – 3, , Semester IV, Two Papers, Two Papers, Two Papers, Practical, Note:, , In the IVth Semester, the candidate shall have to opt minimum of two elective papers of a particular, specialization e.g. Inorganic/Organic/Physical. The candidate shall not be allowed to opt papers from different, specializations, i.e. two elective papers are to be taken positively from one specialization, e.g. one from, Inorganic and one from organic shall not be allowed, similarly other combinations shall not be allowed. The, candidate shall have to do a minimum of five lab experiments from the list of the experiments given in the, syllabus. He/ She will have to do a Project. The topic of the project shall be allotted to him/her by the Project, Supervisor. Marks shall not be awarded to the candidate on the Project work and instead of marks, Grade A,, , Page 2 of 48

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B,C or D shall be given after the assessment of the project. The submission of the project shall be mandatory for, each candidate and he/she will have to submit the project/dissertation not later than the date of his/her practical, examination., , Pattern of examination theory papers (for odd semesters and each, paper I,II,III, IV and V), A. Theory, Each theory paper shall consist three sections A, B and C., Section A: (Objective type); 20% of total marks (15 marks, one question of 10 parts each, parts of one and half marks. These parts may have one sentence answers; fill in the blanks,, one word answer. All parts will be compulsory)., Section B: (Short answers type with reasoning); 40% of the total marks (24 marks, seven, questions of six marks each, any five have to be attempted)., Section C: (Long answers type); 40 % of the total marks, (24 marks, four questions of fifteen, marks any two have to be attempted)., B. Internal assessment, For each theory paper, an internal assignment (in the form of class test and or assignments, including classroom attendance) of 25 marks for each paper shall be conducted during each, semester. Maximum 10 marks can be given to the student having 75% or above attendance., The evaluated answer sheets/assignments have to be submitted to the Head of the, Department/ Principal along with one copy of award list. Two copies of the award list have, to be submitted to the controller examination in a sealed envelope., C. Practical, The practical work of the students has to be evaluated periodically. The internal assessments, (in the form of lab test, lab record, internal evaluation, assignment/home assignment and, attendance) of total 15 marks for each semester shall be conducted during the semester. A, minimum of 12 experiments covering all the kinds of exercises have to be conducted during a, semester. Maximum 10 marks in attendance can be given to students. In each semester,, practical examination of 75 marks has to conducted by two examiners (External and, internal) having duration of time 8 hours. The total number of students to be examined per, batch should not be more than sixty.One copy of award list of the practical examinationalong, with attendancehas to be submitted to the Head of the Department/ Principal. Two copies of, the award lists and attendancehave to be submitted to the controller examination in a sealed, envelope., D. Instructions, Note to be mentioned in each theory paper: This question paper consists of three sections, Section A having 10 objective type compulsory questions (one word, one sentence/fill in the, blanks) carrying one and half marks each (20% of the total marks). Section B consists of, seven short answer type questions with logical approach carrying six marks each. Attempt, any five questions from this section (40% of the total marks). Section C consists of four long, answer type question carrying 15 marks each. Attempt any two questions from this section, (40% of the total marks)., , Page 3 of 48

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Questions are to be attempted section wise sequentially as far as possible. If the student, attempts more questions, the marks will be allotted sequentially. The attempt of extra, question will be treated as cancelled during the evaluation., , SEMESTER I Paper I, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG101, Course Title: M.Sc., Subject Area : Inorganic Chemistry-1, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage, Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of Sidgwick and Powel theory, Objective of Course :,  Essence of hybridization.,  Characteristic of hybrid orbitals.,  Use of VSEPR theory in explaining the shape of molecules.,  Characteristic of borides,carbonyls,carbides,nitrides.,  Metal ligand equilibrium., , 9. Details of Course:, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Lecturer, 12, 1. (a)Stereochemistry and Bonding in Main Group Compounds, Origin of VSEPR theory and its significance in main group Lectures, structural chemistry, structure of SF4,TeF5 - ,BrF3, ICl2-,ICl4 -, OF2,, OSF4 , XeF6 and IF7,dπ-pπ bonds, Bent rule and energetics of, hybridization, some simple reactions of covalently bonded, molecules., (b) Compounds of Boron, Carbon and Nitrogen with Metals, :Metal borides, carbides and nitrides: preparation, properties,, structures and application., 2. Metal-Ligand Equilibria in Solution:Concept of thermodynamic 9 Lectures, and kinetic stabilities of metal complexes. Stepwise and overall, formation constants and their correlations, trends in stepwise, constants, factors affecting the stability of metal complexes with, reference to the nature of metal ion and ligand, chelate effect and, its thermodynamic origin, determination of binary formation, constants by pH-metry and spectrophotometry, 3. Metal 𝝅-Acid Complexes: Metal carbonyls: structure and 9 Lectures, bonding, vibrational spectra of metal carbonyls for bonding and, structural elucidations, important reactions of metal carbonyls;, Page 4 of 48

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4, , 5, , preparation, bonding, structure and important reactions of, transition metal nitrosyls, complexes ofdinitrogen, dioxygen and, tertiary phosphine., 4. Cluster Compounds: Higher boranes, carboranes, metalloboranes 9 Lectures, and metallocarboranes. Metal carbonyl and metalhalide clusters., Clusterswith metal-metal multiple bonds., 5. Polyoxometalates:Isopoly and heteropoly acids and salts (or 9 Lectures, anions) with special reference to vanadium, molybdenum and, tungsten. Nomenclature, classification, preparation and structural, aspects of poly acids and polyanions., , Books Recommended:, i. F. A. Cotton, G. Wilkinson, C.A. Murillo and M. Bochmann, Advance Inorganic, Chemistry, John Wiley & Sons , New York., ii. J. D. Lee, Concise Inorganic Chemistry, Oxford University Press., iii. Atkins, Overton, Rourke, Weller and Armstrong, Inorganic Chemistry, Oxford, University Press., iv. J. E. Huheey, E. A Keiter and R. L. Keiter, Inorganic Chemistry Principles of, Structure and Reactivity, Pearson Education., v. W. W. Porterfield, Inorganic Chemistry: A Unified Approach, Elsevier., vi. G. Wulfsberg, Inorganic Chemistry, Viva Books., vii. G. L. Miessler and D. A. Tarr, Inorganic Chemistry, Pearson Education., , SEMESTER I Paper II, , , , , , , , , 1. Subject Code :CHPG102, Course Title: M.Sc., 2. Subject Area : Organic Chemistry-1, 3. Course Hour, Lecture : L 48, T:10, P:60, 4. Exam Time, Theory:3 hours, Practical : 8 hours, 5. Relative weightage, Theory: 80, Practical :20, 6. Credits :, 7. Pre requisite :, 8. Objective of Course :, Molecular symmetry and chirality, Aromaticity in benzenoid and non- benzenoid compounds., Delocalised chemical bonding, PMO approach, Configuration,nomenclature,D,L,R,S and E, Z nomenclature., Stereochemistry of compounds containing N,S and P chirogenicity,, Page 5 of 48

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x. Ernest L. Eliel andSamuel H.Wilen, Stereochemistry of Organic Compounds, Wiley, India, xi. Ernest L.Eliel, Stereochemistry of Carbon Compounds. Tata McGraw Hill., , SEMESTER I Paper III, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code:CHPG103, Course Title: M.Sc., Subject Area : Physical Chemistry-1, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage, Theory: 80, Practical :20, Credits :, Pre requisite :, Objective of Course :,  Nerst theorem, spontaneity,  Partial molar properties,  Gibbs-Duhem equation,  Collision theory of reaction rates,,  Steric factor,,  Activated complex theory,  Ionic reactions,  Kinetic salt effects., 9. Details of Course:, S.No., , 1, , Contents, , Contact, Hours/, Lectures, 1. Thermodynamics:Laws of thermodynamics: Fundamental 24, concepts, state and path dependent functions, determination of Lectures, work done, enthalpy change, and internal energy change in, reversible and irreversible expansion and compression, entropy, and its calculations, residual entropy, zero, first, second, third law, of thermodynamics and their applications. Nerst theorem,, spontaneity, free energy and its calculation, properties of, Helmholtz free energy and Gibb’s free energy, thermodynamic, equilibria and free energy functions, Clausius-Claypeyron, equation, chemical potential and entropies., Partial molar properties; partial molar free energy, partial molar, volume and chemical potential and their significance, GibbsDuhem equation, methods of determination of partial molar, quantities, Concept of fugacity and its determination, chemical, potential and fugacity, thermodynamic functions of mixing., Non-ideal systems; Excess functions for non-ideal solutions,, Page 8 of 48

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2, , activity, activity coefficient, Debye-Hückel theory for activity, coefficient of electrolytic solutions, determination of activity, coefficients, ionic strength, application of phase rule to three, component systems., 2. Chemical Dynamics :Third and general order reactions, 24, Experimental methods for kinetic studies, viz; conductometric, Lectures, potentiometric and spectrophotometeric methods, effect of, temperature on rate of reaction, Arrhenius equation.Chemical, molecular dynamics: Collision theory of reaction rates, steric, factor, activated complex theory, comparison of collision and, activated complex theories, ionic reactions, kinetic salt effects,, steady state concept, kinetic and thermodynamic control of, reactions. Kinetics of gaseous reactions on solid surface,, unimolecular and bimolecular surface reactions, kinetics of, condensation and addition polymerization reactions, mechanism of, H2-Br2, H2-Cl2 reactions, decomposition of the following, compounds : acetaldehyde, ozone and H2O2., , Books Recommended:, i. B. R. Puri, L. R. Sharma and M. S. Pathnia, Physical Chemistry, Milestone Publisher, & Distributors, New Delhi., ii. K. L. Kapoor, Physical Chemistry. Macmillan Publishers India Limited., iii. K. J. Laidler,Kinetics, Pearson Education India., , SEMESTER I Paper IV, , , , , , , , , , 1. Subject Code :CHPG104, Course Title: M.Sc., 2. Subject Area : Group Theory and Instrumentation Chemistry-1, 3. Course Hour, Lecture : L 48, T:10, P:60, 4. Exam Time, Theory:3 hours, Practical : 8 hours, 5. Relative weightage, Theory: 80, Practical :20, 6. Credits :, 7. Pre requisite :, 8. Objective of Course:, Symmetry elements and symmetry operations., Conjugacy relation and classesof symmetry operations,point symmetry (or group) and, its classification, X-ray structural analysis of crystal, Introduction of electron diffraction, Application of TLC, Column and HPLC, Ion exchange chromatography: Cationic .anionic exchangers and their applications., Page 9 of 48

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9. Details of Course :, , S.No., , 1, , 2, , 3, , 4, , Contents, , Contact, Hours/, Lectures, 1. Symmetry and Group Theory in Chemistry: Symmetry 16, elements and symmetry operations, definitions of group and Lectures, subgroup and their characteristics, relation between orders of and, subgroup and their characteristics, relation between orders of a, finite group and its subgroup. Conjugacy relation and classes of, symmetry operations, point symmetry (or group) and its, classification, Schonfliess symbols, representation of group by, matrices (representation for the Cn, Cnv, Cnh etc. groups to be, worked out explicity), products of symmetry operations. Character, of a representation. The great orthogonality theorem (without, proof) and its importance. Character tables and their use in, spectroscopy., (a) X-ray Diffraction Methods: Bragg condition, Miller 12, indices,Laue’s method, Bragg’s method, Debye- Scherrer method Lectures, of X-ray structural analysis of crystals. Description of the, procedure for an X-ray structure analysis, absolute configuration, of molecules. Ramchandran diagram., (b) General Introduction of Electron Diffraction: Scattering intensity, vs scattering angle, Wierl equation, measurement technique,, elucidation of structure of simple gas phase molecules., Chromatographic methods: Principle, instrumentation and 15, applications of gas and liquid chromatography., Lectures, Principle and application of TLC, paper, column and HPLC. Ion, Exchange chromatography: Cationic, anionic exchangers and their, applications., Gas Chromatography: Theory of gas chromatography, parts of gas, chromatograph, detectors (TCD, FID, ECD), Van-Deemter, equation (no derivation), concept about HEPT- plate theory and, rate theory. Applications., Radio Analytical Methods:Basic principles and types of 5 Lectures, measuring instrument, isotope dilution techniques- principle of, operations and uses. Applications., , Books Recommended, i. F.A. Cotton, Chemical Application of Group Theory, Wiley., ii. D. C. Harris, Bertolucci, Symmetry and Spectroscopy: An Introduction to Vibrational, and Electronic Spectroscopy, Dover Publications, New York., , iii. P. K. Bhattacharya, Group Theory and its Chemical Applications,, Himalaya Publishing House, Mumbai., Page 10 of 48

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iv. Gurdeep Raj, Ajay Bhagi and Vinod Jain, Group Theory and Symmetry, in Chemistry, Krishna Prakashan Media (P) Ltd., Meerut., SEMESTER I Paper V, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG105(a), Course Title: M.Sc., Subject Area : Biology for Chemist (For Mathematics Students)-1, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage, Theory: 80, Practical :20, Credits :, Pre requisite :Introduction and discovery of cell, Objective of Course:,  Cell size and shape,  Cell membrane and wall,  Chloroplast,  Nucleosides,  Cell respiration and metabolism, 9. Details of Course :, S.No., , 1, , 2, , 3, , 4, , Contents, , Contact, Hours/, Section A, Lectures, 1. Cell as Unit of Lite: The cell theory; prokaryotic and eukaryotic 12, and eukaryotic cells; cell size and shape; Eukaryotic cell Lectures, components, 2. Cell Organelles: Mitochondria: Structure, marker enzymes, 12, composition; function. Chloroplast: Structure, marker enzymes, Lectures, composition; semiautonomous nature, chloroplast DNA. ER,, Golgi body and Lysosomes : Structures and roles of ER,, Golgibody and lysosomes Nucleus: Nuclear Envelope- structure of, nuclear pore complex; chromatin; molecular organization, DNA, packaging in eukaryotes, euchromatin and heterochromatin,, nucleolus and ribosome structure (brief). Nacleoside and, Nacloeotides and DNA structure, Cell Membrane and Cell Wall: The functions of membranes; 12, Models of membrane structure; faces of the membrane, selective Lectures, permeability of permeability of the membranes; cell wall, Metabolism: Introduction, basal metabolic rate (BMR),, Carbohydrate protein and lipid metabolism, cell respiration,, amaerabic respiration, aerobic respiration, formation of acetal, COA, citric acid cycle, electron transport system,, adenosinetnphosphate, mechanismy ATP generation, Page 11 of 48

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Books Recommended:, i. P. H.Raven, Biology, Tata MacGraw Hill., ii. P. Sheeler, Cell and Molecular Biology, John Wiley., iii. N. A. Campbell, Biology Pearson., iv. L.Styer, Biochemistry, Freeman & Co., v. Outlines of biochemistry. Fourth edition (Conn, Eric E.; Stumpf, P. K.). Wiley India, Pvt. Limited, , SEMESTER I Paper V, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG105(b), Course Title: M.Sc., Subject Area : Mathematics for Chemist (Only for biology students)-1, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of fundamental algebra and geometry, Objective of Course :Student should know,  About mathematical function,  Graph and Variables,  Differential formulas and integration formulas,  Matrix and determinateness,  Concept of coordinates, , 9. Details of Course:, S.No., , Contents, , Section A, 1, , 2, , 3, , 4, , 5, , 3. Mathematical Functions:Polynomial expression, exponential, function, trigonometrically function. inverse trigonometrically, function. Logarithms and anti logarithms, 4. Curve Sketching/Graph: Inclination of a line and the slope of a, line, General equation of straight line, slope-intercept form,, slopepoint form. Two point form, Intercept form, Parallel and, perpendicular lines, 5. Differentiation: Differentiation formulas, Concept of maximum, and minimum, Rules of finding maxima and minima, Partial, differentiation, Euler reciprocal relation, exact and in exact, differentials, Chain rule for partial differential, 6. Integration: Methods of integrations, substitution, partial, function, by parts, successive, reduction, integration formulas, including concept of limit, Fundamentals of Mathematical Relations: Permutations and, Page 12 of 48, , Contact, Hours/, Lectures, 08, Lectures, 08, Lectures, , 08, Lectures, , 09, Lectures, 15

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Combination, Probability, vectors mathematical relations, Vectors, Lectures, Matrices, Determinants, Complex number, Series, Stirling, approximation, Roots of quadratic equation. Methods of solving, equation. Coordinate systems in three dimensions (Cartesian,, spherical and polar)., Books Recommended:, i., , D.A. McQuarrie, Mathematics for physical Chemistry University Science Books., , ii. R.Mortimer, Mathematics for Physical Chemistry, 3rd Ed. Elsevier., iii. E. Steiner, The Chemical Maths Books, Oxford University Press., CHPG 10P Laboratory Course, 08 hrs, A: Inorganic Chemistry, (I) Qualitative Analysis, 18, Qualitative analysis of mixtures of salts containing not more than eight radicals, including:, (i) Rare-earth element salts (two rare element ions), (ii) Interfering radicals, (iii) Other anions, which have not been done in under graduate practical., (iv) Insolubles and simple salts, (II) Preparations, Preparation of selected inorganic compounds such as:, 12, 1. [Ni(dmg)2], 7., Prussian Blue, Tumbull’s Blue, 2. [Cu(NH3)4]SO4.H2O, 8., Co[NH3)6][Co(NO2)6], 3. Cis-K[Cr(C2O4)2(H2O)2], 9., Cis-[Co(trien)(NO2)2]Cl.H2O, 4. Na[Cr(NH3)2(SCN)4], 10., Hg [Co(SCN)4], 5. [Mn(acac)3, ], 11., [Co(py)2Cl2], 6. K3[Fe(C2O4)3], 12., [Ni(NH3)6]Cl2, OR, Quantitative estimation of metal ions by complexometric titration, direct and / or back, titration, use of masking agents., 12, B. Organic Chemistry, 1. Quantitative Analysis, 18, i. Determination of the percentage of number of hydroxyl groups in an organic compound, by acetylation method., ii. Estimation of amines/ phenols using bromate-bromide solution/ or acetylation, method., iii. Determination of Iodine and Saponification values of an oil sample., iv. Determination of DO, COD and BOD of water sample., v. Separation & identification of two compounds system., 2. Spectrophotometric (UV/VIS) Estimations, 12, (i) Amino acids, (v) Ascorbic acid, (ii) Proteins, (vi) Aspirin, (iii) Carbohydrates, (vii) Caffeine, Page 13 of 48

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(iv) Cholesterol, or, Separationand identification of two compound system., Note: Allocation of marks-Inorganic exercise 30; Organic exercise 30; Record, (including test) 15; attendance 10; viva 15, , SEMESTER II Paper I, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG201, Course Title: M.Sc., Subject Area : Inorganic Chemistry-2, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of molecular orbital’s and bonding in metals, Objective of Course : Students should know,  Kinetic application of CFT and VBT,  Hydrolysis,  Mechanism of the substitution reaction.,  Mechanism of electron transfer reaction,  Marcus-Hush theory, 9. Details of Course :, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Lecturer, 1. Metal- Ligand Bonding :Limitations of crystal field theory, 8Lectures, molecular orbital theory, octahedral, tetrahedral and square planar, complexesπ-bonding and molecular orbital theory., 2. Reaction Mechanism of Transition Metal Complexes:Energy, profile of a reaction, reactivity of metal complexes, kinetic, application of valence bond and crystal field theories, kinetics of, octahedral substituion, acid hydrolysis, factors affecting acid, hydrolysis, base hydrolysis, conjugate base mechanism, direct and, indirect evidences in favour of conjugate mechanism, anation, reactions, reactions without metal ligand bond cleavage., Substitution reactions in square planar compelxes, the trans effect,, mechanism of the substitution reaction. Redox reactions, electron, transfer reactions, mechanism of one electron transfer reactions,, outer-sphere type reactions. Complimentary and noncomplimentary electron transfer reactions, cross reactions and, Marcus-Hush theory, inner sphere type reactions., 3. Electronic Spectra and Magnetic Properties of Transition, Metal Complexes, Spectroscopic ground states correlation,, Orgel and Tanabe-Sugano diagrams for transition metal, Page 14 of 48, , 20, Lectures, , 20, Lectures

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complexes (d1-d9 states), calculations of Dq, B and β parameters,, charge transfer spectra, spectroscopic method of assignment of, absolute configuration in optically active metal chelates and their, stereochemical information, magnetic properties of complexes of, various geometries based on CFT, spin free- spin paired, equilibrium in octahedral stereochemistry, anomalous magnetic, moments, magnetic exchange coupling and spin crossover., , Books Recommended :, i. F.A. Cotton, G. Wilkinson, and Paul L. Gaus, Basic Inorganic Chemistry, 3rd Edition, John Wiley &Sons , New York., ii. J.D. Lee, Concise Inorganic Chemistry, 5th Edition, Wiley& Sons., , SEMESTER II Paper II, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG202 Course Title: M.Sc., Subject Area : Organic Chemistry-2, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : The knowledge of aliphatic compounds and valency of carbon, Objective of Course : Students should know,  Mechanism SE2, SE1,  Diazonium Coupling.,  Effect of solvents on reactivity,  Thypes of pre radical reaction,  E2,E1 and E1 cB mechanism and their spectra.,  Grigrand reagent,  Name reactions., 9. Details of Course :, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Lectures, 1. Aliphatic ElectrophillicSubstituion: Biomolecular mechanisms- 8 Lectures, SE2 and SE1. The SE1 mechanism, electrophilic substitution, accompanied by double bonds shifts. Effect of substrates, leaving, group and the solvent polarity on the reactivity, 2. Aromatic Electrophilic Substitution :The arenium ion 8 Lectures, mechanism, orientation and reactivity, energy profile diagrams., The ortho/para ratio, ispo attack, orientation in other ring systems., Quantitative treatment of reactivity in substrates and electrophiles., Diazonium coupling., 3. Free Radical Reactions: Types of free radical reactions, free 8 Lectures, radical substitution mechanism, mechanism at an aromatic, Page 15 of 48

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4, , 5, , 6, , substrate, neighbouring group assistance. Reactivity for aliphatic, and aromatic substrates at a bridgehead. Reactivity in the attacking, radicals. The effect of solvents on reactivity. Allylic halogenation, (NBS), oxidation of aldehydes to carboxylic acids, autooxidation,, coupling of alkynes and arylation of aromatic compounds by, diazonium salts. Free radical rearrangements., 4. Addition to Carbon-Carbon Multiple Bonds: Mechanistic and Lectures, stereochemical aspects of addition reactions involving, electrophiles, nucleophiles and free radicals, regio-and, chemoselectivity, orientation and reactivity. Addition to, cyclopropane ring. Hydrogenation of double and triple bonds,, hydrogenation of aromatic rings. Hydroboration.., 5. Addition to Carbon-Hetero Multiple BondsMechanism of metal Lectures, hydride reduction of saturated and unsaturated carbonyl, compounds, acids, esters and nitriles. Addition of Grignard, reagents, organozinc and organolithium reagents to carbonyl and, unsaturated carbonyl compounds. Hydrolysis of esters and amides,, ammonolysis of esters., Elimination and Name Reactions: The E2, E1 and E1cB 10, mechanisms and their spectrum. Orientation of the double bond. Lectures, Reactivity-effects of substrate structures, attacking base, the, leaving group and the medium. Mechanism and orientation in, pyrolytic elimination Vilsmeier reaction, Gattermann-Koch, reaction, Sandmeyer reaction, Hunsdiecker reaction, Michael, reaction. Sharpless asymmetric epoxidation, Aldol, Knoevenagel,, Claisen, Mannich, Benzoin, Perkin and Stobbe reactions, Wittig, reaction , Heck reaction , Still reaction, Sonogarishira, Negishi, coupling, Grubbs Catalyst., , BOOKS SUGGESTED:, i., Jerry March, Advanced Organic Chemistry Reactions, Mechanism and Structure,, John Wiley., ii., RT Morrison and RN Boyd Organic Chemistry, , Prentice Hall., iii., CK Ingold, Structure and Mechanism in Organic Chemistry, Cornell University, Press., iv., SM Mukherji and SP Singh, Reaction Mechanism in Organic Chemistry,, Macmillan., v., D Nasipuri, Stereochemistry of Organic Compounds, New Age International, vi., PS Kalsi, Stereochemistry of Organic Compounds, New Age International., vii., SM Mukherjee, Pericyclic Reactions, Macmillan, India., viii., FA Carey and RJ Sundberg,Advanced Organic Chemistry, Plenum., ix., Modern Organic Reactions, HO House, Benjamin., x., Ernest L. Eliel, Samuel H Wilen, Stereochemistry of Organic Compounds, Wiley, India, xi., Ernest L Eliel, Stereochemistry of Carbon Compounds. Tata McGraw Hill., Page 16 of 48

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SEMESTER II Paper III, 1., 2., 3., 4., 5., 6., 7., , Subject Code : CHPG203, Course Title: M.Sc., Subject Area : Physical Chemistry-2, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite :The knowledge of electrolytes, surfaces and ionization. Concept of, atomic structure., 8. Objective of Course : Students should know,  Adsorption,  BET equation,  Debye-Huckel-Onsagar theory,  Operators,  Schrodinger’s equation and its application., 9. Details of Course :, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Lectures, Surface and Polymer Chemistry: Gibb’s adsorption isotherm, 16, Freundlich and Langmuir adsorption isotherms, determination of Lectures, free energy of adsorption, BET theory for multilayer adsorption, with derivation, determination of surface area using BET method,, catalytic activity at surfaces, macromolecules, polymers and their, general applications, classification of polymers, chain, configuration of polymers, liquid crystals and their applications., Molecular mass, number and mass average molecular mass,, molecular mass determination using osmometry, viscometry,, diffusion and light scattering methods., 3. Electrochemistry : Determination of activity coefficient, Debye- 16, Huckel theory of strong electrolytes with derivation, ionic Lectures, atmosphere and thickness of ionic atmosphere, Debye-HuckelOnsagar theory, theory of conduction, Onsagar equation including, mathematical deduction, overvoltage and decomposition potential., .Quantum Chemistry: de-Broglie concept and de-Broglie 16, equation, physical interpretation and properties of wave functions, Lectures, Linear, Laplacian, Linear-momentum and Hamiltonian operators,, postulates of quantum mechanics, eigen values, eigen functions,, normalization and orthogonalizaion, derivation of the, Schrodinger’s wave equation, concept of cartesian and spherical, coordinates, general and brief discussion on the applications of, Schrodinger’s wave equation to some model systems viz. particles, in a box, harmonic oscillator, rigid rotator and hydrogen atom., Page 17 of 48

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4., , Books Recommended :, Puri Sharma and Pathniya, Physical Chemistry, vishal Publication 2011., ii. K.L. Kapoor, Physical Chemistry, Macllian, iii. Kinetics by Laidler, Pearson, i., , SEMESTER II Paper IV, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG204 Course Title: M.Sc., Subject Area : Spectroscopic Techniques-2, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : The knowledge of interaction of radiation with matter., Objective of Course : Students should know,  Mode of vibrations and group frequencies in IR,  PQR branches,  Solvent effect on IR spectra,  Mossbaures spectra,  UV visible and Raman Spectra, 9. Details of Course :, S.No., , 1, , 2, , Contents, , Contact, Hours/, Lectures, Electron Spin Resonance Spectroscopy: Basic Principles, zero 16, field splitting and Kramer’s degeneracy, factors affecting the ‘g’ Lectures, value. Hyperfine coupling isotopic and anisotropic hyperfine, coupling constants, spin Hamiltinian, spin densities, measurement, techniques, spin polarization for atoms and transition metal ions,, spin-orbit coupling and significance of g-tensors, application to, inorganic and organic free radicals and to transition metal, complexes (having an unpaired electron) including biological, systems., Nuclear Magnetic Resonance Spectroscopy: Nuclear Spin, 16, nuclear resonance, saturation, shielding of magnetic nuclei, Lectures, chemical shift and its measurements, factors influencing the, chemical shift. Deshielding, spin-spin interaction, factors, influencing coupling constant (J). Classification (ABX, AMX,, ABC, A2B2 etc.), spin decoupling, basic idea about instruments,, NMR studies of nuclei other than proton; 13C, 19F and 31P., Advantages of FT NMR. Use of NMR in medical diagnostics., Simple problems and interpretation. NOE, simplification of, complex spectra by the use of Shift reagent and field strength., Page 18 of 48

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3, , Nuclear Overhauser Effect (NOE).13C NMR spectroscopy:, general considerations, chemical shift (aliphatic, olefinic, alkyne, and aromatic hetero aromatic and carbonyl carbon). Coupling, constants., Mass Spectrometry: Introduction, ion production-EI, CI, FD and 16, FAB, factors affecting fragmentation , ion analysis, ion Lectures, abundance. Mass spectral fragmentation of organic compounds,, common functional groups, molecular ion peak, metastable peak,, McLafferty rearrangement. Nitrogen rule, example of Mass, fragmentation of organic compounds with respect to their structure, determination. Problems based on spectroscopic techniques., , BOOKS SUGGESTED:, i., Pavia, Lampman, Kriz, Spectroscopy, Books/Cole; Vyvyan, ii., PS KalsiSpectroscopy of Organic Compounds, New Age International Publishers;, iii., Silverstein, Robert M.; Webster, Francis X.; Kiemle,Spectrometric Identification, of Organic Compounds, John Wiley;, iv., ML Martin, JJDelpeach and GJ Martin, Heyden, Practical NMR Spectroscopy,, v., Colin N. Banwell and Elaine M. Mc Cash, Fundamentals of Molecular, Spectroscopy, Tata McGraw Hill., vi., RJ Abraham, J Fischer and P Loftus, Introduction to NMR Spectroscopy, Wiley., vii., DH Williams, I Fleming, Spectroscopic Method in Organic Chemistry: Tata, MacGraw Hill., viii., Willard Merritt, Dean, Settle,Instrumental Method of Analysis: Seventh Edition,, CBS, Publication., Laboratory course : CHPG20P, 08 hrs, A. Physical Chemistry, 30, (i) Determination of the velocity constant of acid catalyzed hydrolysis of an ester., (ii) Determination of activation energy of a reaction., (iii) Determination of Frequency factor of a reaction by kinetic studies., (iv) Validity of Arrhenius equation., (v) Determination of the effect of change in temperature on rate constant of a reaction., (vi) Determination of the effect of change in concentration of the reactants on rate constant of, a reaction., (vii) Determination of the effect of change in concentration of the catalyst on rate constant, of a reaction., (viii) Determination of the effect of change in ionic strength on the rate constant of a, reaction., (ix) Determination of the rate constant for the oxidation of iodide ions by hydrogen peroxide., (x) Flowing Clock reactions (Ref. Experiments in Physical Chemistry by Showmaker)., (xi) Study of the adsorption of an acid by charcoal., (xii)Validity of Freundlich’s Adsorption isotherm., (xiii) Determination of Partition Coefficients., (xiv) Determination of molecular surface energy of a liquid by Stalagmometer method., Page 19 of 48

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(xv) Determination of association factor of the given liquid by drop-pipette method., Note: The candidates shall have to do a minimum of 05 experiments., B. Organic Chemistry, 30, 1. Multi-step Synthesis of Organic Compounds, 18, The exercises should illustrate the use of organic reagent and may involve purification of the, products by chromatographic techniques., (i) Photochemical reaction:, BenzophenoneBenzpinnacolBenzpinacolone, (ii) Beckmann rearrangement: Benzanilide from benzene, Benzene, BenzophenoneBenzophenoneoximeBenzanilide., (iii)Benzilic acid rearrangement: Benzilic acid from benzoin, Benzoin, BenzilBenzilic acid, (iv) Synthesis of hetrocylic compounds, Skraup synthesis: Preparation of quinoline from aniline., Fischer indolsynthsis: Preparation of 2-phenyl indole from phenylhydrazine., (v) Enzymatic synthesis, Enzymatic reduction: Reduction of ethyl acetoacetate using Baker’s yeast to yield, enantiomeric excess of S(+)ethyl-3-hydroxybetanoate and determine its optical purity., Biosynthesis of ethanol from sucrose, (vi) Synthesis using microwaves, (vii) Alkylation of diethyl malonate with benzyl chloride., (viii) Synthesis using phase transfer catalyst, (ix) Alkylation of diethyl malonate or ethylacetoacetate with an alkyl halide., (x) Paper Chromatography/Thin Layer Chromatography, 12, Separation and identification of the sugars present in the given mixture of glucose, fructose, and sucrose etc. By Paper chromatography, thin layer chromatography and, determination of Rf values., Note: Organic exercise 30; Physical 30; Record(including test) 15; attendance 10;viva15, , SEMESTER III Paper I, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG301, Course Title: M.Sc., Subject Area : Solid State Chemistry-3, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage, Theory: 80, Practical :20, Credits :, Pre requisite :The knowledge of solids, Objective of Course :,  Structure of solid-band theory,  Types of conductor,  Crystal defects,  Electrically conducting solids,  Super conductors and fullerenes, Page 20 of 48

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9. Details of Course :, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Section A, Lectures, Solid State Reactions, Crystal Defects and Non-stoichiometry: 16, General principles, experimental procedures, co-precipitation as a Lectures, precursor to solid state reactions, kinetics of solid state reactions,, Perfect and imperfect crystals, intrinsic and extrinsic defects- point, defects, line and plane defects, vacancies- Schottky defects and, Frenket defects, Electronic Properties and Band theory: Metals, insulators and 16, semiconductors, electronic structure of solids-band theory. Band Lectures, structure of metals, insulators and semiconductors. Intrinsic and, extrinsic semiconductors, doping semiconductors, p-n junctions,, super conductors., Organic Solids, Fullerenes, MolecularDevices: Electrically 16, conducting solids, organic charge transfer complexes, organic Lectures, metals, new super conductors, magnetism in organic materials,, fullerenes- doped, fullerenes as superconductors. Molecular, rectifiers and transistors, artificial photosynthetic devices, optical, storage memory and switches sensors., , Books Recommended, i. G.W. Castellan, Physical Chemistry, 4th Ed. Narosa., ii. R.G. Mortimer, Physical Chemistry, 3rd Ed. Elsevier: NOIDA, UP., , SEMESTER III Paper II, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG302, Course Title: M.Sc., Subject Area : Spectroscope Techniques -3, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage, Theory: 80, Practical :20, Credits :, Pre requisite :The knowledge of interaction of radiations with matter, Objective of Course :,  Molecular dissymmetry,  Electronic transitions,  ORD and CD curves,  Characteristics vibration frequencies of compound, 9. Details of Course :, Page 21 of 48

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S.No., , 1, , 2, , 3, , 4, , 5, , Contents, , Contact, Hours/, Lectures, MössbauerSpectroscopy:Basic principles, spectral parameters 9 Lectures, and spectrum display. Application of the technique to the studies, of (i) bonding and structure of Fe++ and Fe+++ compounds (ii) Sn+2, and Sn+4 compounds-nature of M-L bond, coordination number,, structure and iii) detection of oxidation state and inequivalent, MB atoms., Ultraviolet and Visible Spectroscopy:Various electronic 9 Lectures, transitions (185 to 800 nm), Lambert-Beer’s Law, effect of solvent, on electronic transitions, ultraviolet bands for carbonyl, compounds, unsaturated carbonyl compounds, diens, conjugated, polyenes. Fieser-Woodward rules for conjugated diens and, carbonyl compounds, ultraviolet spectra of aromatic and, heterocyclic compounds., Molecular Dyssemetry and ChiropticalProperties:Linear and 7 Lectures, circularly polarized lights, circular birefringence and circular, dichroism, ORD and CD curves, Cotton effects. The axial helo, ketone rule, Octent diagrams, Helicity and Lowe’s Rule., Application of ORD and CD to structural and stereochemical, problems, Infrared Spectroscopy: Instrumentation and simple handling. 15, Selection rules, normal modes of vibration, group frequencies, Lectures, overtones, hot bands, factors affecting the bond positions and, intensities, Characteristic vibrational frequencies of alkanes,, alkenes, alkynes, aromatic compounds, alcohols, ethers, phenols,, amines and carbonyl compounds (ketones, aldehydes, esters, ,amides, acids anhydrides, lactones, lactams and conjugated, carbonyl compounds). Effect of hydrogen bonding, solvent effect, on IR of gaseous, solids and polymeric materials. Review of linear, harmonic oscillator, vibrational energies of diatomic molecules,, zero point energy, force constant and bond. Strength’, anharmonicity, Morse potential energy diagram, vibration-rotation, spectroscopy, P,Q,R branches. Breakdown of Oppenheimer, approximation; vibrations of polyatomic molecules. far IR region,, metal-ligand vibrations, normal co-ordinate analysis. Simple, applications., Raman Spectroscopy: Classical and quantum theories of Raman 8 Lectures, effect. Pure rotational, vibrational and vibrational-rotational, Raman spectra, selection rules, mutual principles. Resonance, Raman spectroscopy, Coherent anti-stokes Raman Spectroscopy, (CARS), Simple applications., , BOOKS SUGGESTEDPage 22 of 48

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i., ii., iii., , Pavia, Lampman, Kriz and VyvyanSpectroscopy, Books/Cole, P. S.Kalsi,Spectroscopy of Organic Compounds, New Age International Publishers., Robert M.Silverstein, Francis X.Webster, and D. J. KiemleSpectrometric Identification, of Organic Compounds, John Wiley, iv. M. L. Martin, J. J.Delpeach G. J. Martin and Heyden,Practical NMR Spectroscopy., v. Colin N. Banwell and Elaine M. McCash,Fundamentals of Molecular Spectroscopy,, Tata McGraw Hill., vi. R. J. Abraham, J. Fischer and P. Loftus,Introduction to NMR Spectroscopy, Wiley., vii. D. H. Williams and I. Fleming, Spectroscopic Method in Organic, Chemistry,TataMacGraw Hill., viii. H. H. Willard,Jr. L. L. Merritt, J. A. Dean and Jr F. A., Settle.CBSPublication.Instrumental Method of Analysis: Seventh Edition,, , SEMESTER III Paper III, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG303, Course Title: M.Sc., Subject Area : Chemistry of Biological System-3, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite :Knowledge of Biological cells and molecules, Objective of Course :Students should know about,  Essential trace metal in biological system,  Transport and storage of dioxication,  Enzyme chemistry,  Bio energetics, 9. Details of Course :, S.No., , 1, , 2, , Contents, , Contact, Hours/, Lectures, Bioinorganic Chemistry: Structure and function of Cell 16, Membrane. Essential and trace metals, role of metal ions in Lectures, biological processes. Ion Transport through cell membrane. Na+/, k+ Pump. nitrogen fixation, metal complexes in transmission of, energy, Haeme proteins and oxygen uptake, function of, metalloproteins, Bioorganic Chemistry: Introduction and historical perspective, 16, Nomenclature and classification, extraction, purification and uses Lectures, of enzymes in food drink industry and clinical therapy. Chemical, Page 23 of 48

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3, , and biological catalysis, remarkable properties of enzymes like, catalytic power, specificity and regulation. Proximity effects and, molecular adaption. Enzyme kinetics, Michaelis-Mentien and, Lineweaver-Burk plots, reversible and irreversible inhibition., Transition state theory, Fisher’s lock and key and Koshland’s, induced fit hypothesis, concept and identification of active site by, site- directed, mutagenesis. Acid-base catalysis, covalent catalysis,, strain or distortion. Example of some typical enzyme mechanisms, for chymotrypsin, ribonuclease, lysozyme, carboxypeptidase A, and Nitrogenase. Coenzyme chemistry:Cofactors as derived from, vitamins, coenzymes, prosthetic groups, apoenzymes. Structure, and biological functions of coenzymes A, thiamine pyrophosphate,, NAD+, NADP+, FMN, FAD, lipoic acid and vitamin B12. Enzyme, catalysed metabolic reactions, Biophysical Chemistry:Forces involved in biopolymer 16, interactions. Electrostatic charge and molecular expansion, Lectures, hydrophobic forces, osmotic pressure, membrane equilibrium., Bioenergetics: Standard free energy change in biological reactions., Hydrolysis of ATP, synthesis of ATP from ADP. Coupling of, ATP cleavage to endergonic processes Size, shape and molecular, mass of biopolymer. Determination of molecular mass of, biopolymers by various experimental techniques., , BOOKS SUGGESTED, i., P.S. Kalsi, Bioorganic, Bioinorganic and Supramolecular Chemistry, New Age, International., ii., L. Stryer, Biochemistry 4th Ed., W. H. Freeman & Co., iii., S.Zubay, Biochemistry Addison-Wesley., iv., S.J.Lippard and J.M.Berg, Principles of Bioorganic Chemistry, University, Science Books., v., I. Berteni, H.B. Gray, S.J. Lippard and J.S. Valentine,Bioinorganic Chemistry, ,, University Science Books., vi., Hermann Dugs and C. Penny, Bioorganic Chemistry: A Chemical Approach to, Enzyme Action, Springer-Verlag., vii., Trevor Palmer, Understanding Enzymes, Prentice Hall., viii. Collins J Sucking, Enzyme Chemistry: Impact and Application, Ed. Chapman and, Hall., ix., M.I. page and A. Williams, Enzyme Mechanisms Ed., Royal Society of, Chemistry., x., N.C. Price and L. Stevens, Fundamental of Enzymology, Oxford University, Press., xi., Michael D. Trevan,Immobilized Enzymes: An Introduction and Application in, Biotechnology, John Wiley., xii., Alan Fersht. Enzyme Reaction and Mechnaism, W H Freeman & Co (Sd)., Page 24 of 48

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xiii., xiv., xv., , A.L. Lehninger, Principles of Biochemistry, Worth Publishers., J. M. Berg, J. L. Tymoczko and L. Stryer,Biochemistry, W.H. Freeman., H. Robert Horton, Laurence A. Moran, Raymond S. Ochs, J. David Rawan and K., Gray Scrimgeour.Principles of Biochemistry,Neil Patterson Publishers/Prentice, Hall, xvi. Donald Voet, Charlotte W. Pratt, Judith G. Voet, Biochemistry, John Wiley., xvii. E.E. Conn and P.K. Stumpf,Outlines of Biochemistry, John Wiley., xviii. L. S. W. H. Freeman, Macromolecules: Structure and Function, Prenctice Hall., xix. PramodPandey, Organic Chemistry, John Wiley., , SEMESTER III Paper IV, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG304, Course Title: M.Sc., Subject Area : Inter disciplinary topics in chemistry-3, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite :Knowledge of General Chemistry and its usages, Objective of Course : Student should have knowledge of,  Chemistry in neno scale,  Chemistry involve in environment,  Green chemistry involve,  QSAR and SAR,  Basics of computer, 9. Details of Course :, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Lectures, Green Chemistry: Basic principles of green chemistry. Designing 10, green reagents: green catalyst phase transfer catalysis for green Lectures, synthesis choice of starting materials, organic synthesis in solid, phase reagents, versatile ionic liquids as Scherrermethode., Nanochemistry: History, definition and scope of nanomaterials , 10, chemical methods for synthesis of nanomaterials, methods of Lectures, charecterization, determination of particle size and surface, structure by Scanning Electron microscopy, Transmission, Electron microscopy, surface area analysis and Debye-Schrrer, method, Data Analysis and Computer:Types of errors, propagation of 10, errors, accuracy and precision, least square analysis, average Lectures, standard deviation. liner regression, co-variance and correlation, coefficient., Page 25 of 48

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4, , 5, , History of development of computers, Main frames, Mini, Micro, and Super Computer systems. General awareness of computer, hardware i.e CPU and other peripheral devices, Basic structure and functioning of computers with a PC as an, illustrative example. Memory, I/Q devices, secondary storage., Computer languages. Operating system with DOS as an example., Introduction to WINDOWS. Data processing, principles of, programming. Algorithms and flowcharts., Environmental Chemistry: Concept and scope, composition of, atmosphere, terminology and nomenclature, aerosols, photo, chemical smog, BOD and COD., Medicinal Chemistry: Primary knowledge of structure activity, relationship, SAR, quantitative structure activity relationship, (QSAR), Chemistry of antineoplastic agents and cardiovascular, drugs, , 09, Lectures, 09, Lectures, , Books Recommended :, i. Geoffrey A. Ozin, and Andre Arsentte,Neno Chemistry, RSC Publishing., ii. A.K. Day, Environmental Chemistry New Age., , SEMESTER III Paper IV, 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code :CHPG305, Course Title: M.Sc., Subject Area : Photo Chemistry-3, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite :Knowledge of photon energy, Objective of Course :Students should have the knowledge of,  Photochemical laws,  Quantum yield and its determination,  Photochemical additions,  Paterno-Buchi reactions,  Norrish type I & II reactions, 9. Details of Course :, S.No., , Contents, , 1, , Basics of Photochemistry: Absorption,excitation,, photochemical laws, electronically excited states-life times,, Page 26 of 48, , Contact, Hours/, Lectures, 6 Lectures

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2, , 3, , 4, , measurements of the times. Flash photolysis, Stopped flow, techniques. Energy dissipation by radiative and non-radiative, processes, absorption spectra, Franck-Condon principle,, Photochemical stages- primary and secondary processes. photophysical reactions,, Jablonskii diagram, photosensitization,, quantum yield and its determination, reactions of high and low, quantum yields with suitable examples, fluorescence,, phosphorescence and chemiluminiscence with suitable examples, Photochemistry of Organic Compounds:Photochemistry of 6 Lectures, alkenes; cis-trans isomerization, non-vertical energy transfer;, photochemical additions; reactions of 1,3- and 1,4-dienes;, dimerisation., Photochemistry of Carbonyl Compounds: Norrish type I & II 6 Lectures, reactions (cyclic and acyclic); α,β-unsaturated ketones; β,γunsaturated, ketones;, cyclohexenones, (conjugated);, cyclohexadienons (cross-conjugated & conjugated); Paterno-Buchi, reactions; photoreductions., Photochemistry of Aromatic Compounds:Isomerisation, 6 Lectures, skeletal isomerisations, Dewar and prismanes in isomerisations., Singlet oxygens reactions; Photo Fries rearrangement of ethers and, anilides; Barton reaction, Hoffmann-Loefller-Freytag reaction., , BOOKS SUGGESTED, i., F.A. Carey, andR. J. Sundberg, Advanced Organic Chemistry, Parts A & B, Plenum:, U.S., ii. W. M. Horspool, Aspects of Organic Photochemistry,Academic Press., iii. T. H. Lowry andK. S. Richardson, Mechanism and Theory in Organic Chemistry, Addison-Wesley Educational Publishers, Inc., iv. J. March, Advanced Organic Chemistry,John Wiley & Sons., v. L. Stryer, Biochemistry, W. H. Freeman & Co., vi. P. A.Sykes, Guidebook to Mechanism in Organic Chemistry, Prentice-Hall., vii. James H. Clark and Duncan J. Macquarrie,Handbook of Green Chemistry and, Technology, Wiley-Blackwell., viii. Paul T. Anastas and Tracy C. WilliamsonGreen Chemistry: Frontiers in Benign, Chemical syntheses and Processes, Oxford University Press., ix. Geoffrey Alan Ozin, A. C. Arsenault and L. Cademartiri, Nanochemistry:, AChemicalApproach to Nanomaterials, Royal Society of Chemistry., , Laboratory Course CHPG 30P, , 08 hrs, , A. Physical Chemistry Practicals, (i) Determination of the order of reaction by isolation method, (ii) Determination of the order of reaction by half life period method, (iii) Determination of the order of the reaction by Integration method., (iv) Determination of the entropy of activation of a reaction., (v) Determination of free energy change of a reaction., (vi) Determination of the equilibrium constant of a reaction., , 30, , Page 27 of 48

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(vii) Determination of pH by electrical conductivity method., (viii) Hydrolysis of the salts by electrical conductivity method, (ix) Hydrolysis of the salts by EMF., (x) Determination of the dissociation constant of a weak acid by conductivity method., (xi) Determination of the equivalent conductivity of a strong electrolyte conductometrically., (xii)Determination of the equivalent conductivity at infinite dilution of weak electrolyte, conductometrically., (xiii) Validity of Ostwald’s dilution law., (xiv) Determination of the degree of dissociation/ association conduct metrically., (xv)Determination of solubility and solubility product of sparingly soluble salts (e.g.,, PbSO4,BaSO4) conductometrically., Note: The candidates shall have to do a minimum of 05 experiments, B. Inorganic Chemistry, 30, 1. Quantitative analysis of binary mixture of metal ions involving volumetric (by, complexometric titration using masking and demasking agents) and gravimetric, analysis., 20, 2. Chromatography: separation of cations and anions by paper/TLC/Ion Exchange, chromatography, 10, Note: Inorganic exercise 30; Physical 30; Record(including test) 15; attendance, 10;viva 15, , SEMESTER IV Paper I, (Elective Paper Inorganic chemistry), 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40I(a), Course Title: M.Sc., Subject Area : General and Organometalic Chemistry-4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : The knowledge of solids, Objective of Course : Students should know,  Reactions of free radicals,  Silicates and Aluminosilicates,  Ligands,  Alikyls aryls and acyls of metals,  Metal carbon multiple bonds,  Homogeneous catalysis and types of reactions, 9. Details of Course :, S.No., , Contents, , Contact, Hours/, Lectures, Page 28 of 48

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iv. R.C. Mehrotra and A. singh, Organometallic Chemistry, New Age International., v. J.E. Huheey, E.A. Keiter, R.L. Keiter,Inorganic Chemistry: Principle of structure and, Reactivity, Pearson Education., vi. N.L.H. Green, Organometallic Compounds, Chapman & Hall, U.K., vii. G.E. Coates, M.L.H. Green., P. Pwell,Principles of Organometallic Chemistry,, Chapman & Hall, U.K., , SEMESTER IV Paper II, (Elective Paper Inorganic chemistry), 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40I(b), Course Title: M.Sc., Subject Area : Inorganic polymer and supromolecular Chemistry -4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : The knowledge of interaction of radiations with matter, Objective of Course : Students should know,  Characteristics of poly-dispersion and polymers,  Concept of supra molecular chemistry,  Boron and silicon based polymers,  Crystal structure and morphology of polymers,  Coordination polymers., 9. Details of Course :, S.No., , 1, , 2, , Contents, , Contact, Hours/, Lectures, Basics : Importance of polymers, basic concepts: monomers, 8 Lectures, repeat units, degree of polymerization. Linear, branched and, network polymers. Classification of polymers, polymerization:, condensation, addition, radical chain-ionic and co-ordination and, co-polymerization. Polymerization conditions and polymer, reactions Kinetics of polymerization. Stererochemistry and, mechanism of polymerization. Polymerization in homogeneous, and heterogeneous systems. Comparison with organic polymers., Polymer Characterization: Polydispersion, average molecular 8 Lectures, weight concept: number average, weight average and viscosity, average molecular weights. Polydispersity and molecular weight, distribution. The practical significance of molecular weight., Measurement of molecular weight: end-group, viscosity, light, scattering, osmotic and ultacentrifugation methods. Analysis and, testing of polymers, chemical analysis of polymers, spectroscopic, methods, X-ray diffraction study. Microscopy. Thermal analysis, and physical testing- tensile strength. Fatigue impact. Tear, resistance. Hardness and abrasion resistance., Page 30 of 48

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3, , 4, , 5, , 6, , Structure and Properties: Morphology and order in crystalline, polymers-configurations of polymer chains: Crystal structures of, polymers. Morphology of crystalline polymers, strain-induced, morphology, crystallization and melting. Polymer structure and, physical properties-crystalline melting point(TM); melting points, of homogeneous series, effect of chain, flexibility and other steric, factors, entropy and heat of fusion. The glass transition, temperature(Tg), relationship between Tm and Tg, effects of, molecular weight, diluents, chemical structure, chain topology,, branching and cross linking. Property requirements and polymer, utilization., Polymer Processing : Plastics, elastomers and fibres., Compounding. Processing techniques: calendering, die casting,, rotational casting, film casting, injection moulding, extrusion, moudling, thermoforming, foaming, reinforcing and fibre, spinning., Boron Based Polymers, Silicon Based Polymers, Phosphorous, Based Polymers and Coordination Polymers: Borazine,, substituted borazines, boron nitride. Boron-oxygen-silicon and, boron-oxygen-phosphorus polymers. Ployhedralborane anions., Silica, feldspars and ultramarines, silicones, silicone fluids,, silicone rubbers, silicone greases, silicone resins and, metallosiloxanes. Silicon-nitrogen polymers and silazenes., Metaphosphates, polyphosphates, cross-linked phosphates., Phosphonitrilic halides and related polymers. Phosphorous-sulphur, polymers., Factors affecting formation of coordination polymers. Types of, coordination polymers. Metal halides. Metal pseudohalides, metal, alkoxides, metal carboxylates and metal chelates, Supramolecular Chemistry: Concepts and LanguageMolecular, recognition: molecular receptors for different types of molecules, including arisonic substrates, design and synthesis of coreceptormolecules and multiple recognition. Strong, weak and, very weak H-bonds, utilization of H-bonds to create, supramolecular structures. Use of H-bond in crystal engineering, and molecular recognition. Chelate and macrocyclic effects.Cation, binding hosts, binding of anions, binding of neutral molecules,, binding of organic molecules. Supramolecular reactivity and, catalysis. Transport processes and carrier design. Supramolecular, devices,, supramolecular, photochemistry,, supramolecular, electronic ionic and switching devices. Some examples of selfassembly in supramolecular chemistry., , 8 Lectures, , 8 Lectures, , 8 Lectures, , 8 Lectures, , BOOKS SUGGESTEDi., , F.W. Bilimever Jr.,Text Book of Polymer Science, Wiley., , ii., , N.V. Vishwanathan and J. Sreedhar, Polymer Science, V.R. Gowarker, Willey-Eastern., Page 31 of 48

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iii., iv., v., vi., vii., , K. Takemoto Y. lnaki and R.M. Ottanbrite, Functional Monomers and Polymers., H.R. Alcock and F.W. Lambe, Contemporary Polymer Chemistry, Prentice Hall., J.M.G. Cowie, Physics and Chemistry of Polymers, Blakie Academic and Professional., N.H. Ray, Inorganic Polymers, Academic Press, N. York., J.M. Lehn, Supramolecular Chemistry, VCH., , SEMESTER IV Paper III, (Elective Paper Inorganic chemistry), 1., 2., 3., 4., 5., 6., 7., , Subject Code : CHPG40I(c), Course Title: M.Sc., Subject Area : Photo Inorganic Chemistry-4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : The knowledge of photon, photon energy and excitation by, absorption of photon by matter, 8. Objective of Course : Students should know about,  Photochemical reactions.,  Mechanism of photo chemical reactions.,  Properties of excited states and metal complexes.,  Redox reaction and legend filed photo chemistry, 9. Details of Course :, S.No., , 1, , 2, , 3, , Contents, , Contact, Hours/, Lectures, Basics of Photochemistry: Absorption, excitation, photochemical 8 Lectures, laws, electronically excited states-life times, measurements of the, times. Flash photolysis, stopped flow techniques. Energy, dissipation by radiative and non-radiative processes, absorption, spectra, Franck-Condon principle, photochemical stages- primary, and secondary processes., Photochemical Reactions: Interaction of electromagnetic 8Lectures, radiation with matter, types of excitations, fate of excited, molecule, quantum yield, transfer of excitation energy,, actinometry. Singlet molecular oxygen reactions. Photochemical, formation, of, smog., Photo-degradation, of, polymers., Photochemistry of vision., Properties of Excited States and Excited States of Metal 8 Lectures, Complexes :Structure, dipole moment, acid-base strengths,, reactivity. Photochemical kinetics-calculation of rates of radiative, processes. Biomolecular deactivation-quenching., Excited states of metal complexes: comparison with organic, compounds, electronically excited states of metal complexes., Charge-transfer spectra, charge transfer excitations, methods for, obtaining charge-transfer spectra., Page 32 of 48

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4, , 5, , 6, , Ligand Field Photochemistry: Photosubsitution, photooxidation 8 Lectures, and photoreduction, lability and selectivity, zero vibrational levels, of ground state and excited state, energy content of excited state,, zero-zero spectroscopic energy, development of the equations for, redox potentials of the excited states., Redox Reacitons by Excited Metal Complexes: Energy transfer 8 Lectures, under conditions of weak interaction and strong interactionexciplex formation, conditions of the excited states to be useful as, redox reactants, excited electron transfer, metal complexes as, attractive candidates (2,2’-bipyridine and 1,10-phenenthroline, complexes), illustration of reducing and oxidizing character of, Ru2+bipyridal complex (comparison with [Fe(bipy)3]); role of spinorbit coupling-life time of these complexes. Application of redox, processes of electronically excited states for catalytic purpose,, transformation of low energy reactants into high energy products,, chemical energy into light., Metal Complex Sensitizers and Determination of Reaction 8 Lectures, Mechanism : Metal complex sensitizer, electron relay, metal, colloid system, semiconductor supported metal or oxide systems,, water photolysis, nitrogen fixation and coarbon dioxide reduction., Classification, rate constants and life times of reactive energy, states-determination of rate constants of reactions. Effects of light, intensity on the rate of photochemical reactions. Types of, photochemical reactions; photo-dissociation, gas-phase photolysis, , BOOKS SUGGESTED, A.W. Adamson and P.D. Fleischauer, Concept of Inorganic Photochemistry, Wiley., , i., ii., iii., iv., v., vi., vii., viii., , Inorganic Photochemistry, J. Chem. Educ., vol. 60, no. 10, 1983., .J. Lippard, Progress in Inorganic Chemistry, Vol. 30, ed. SWiley., Coordination Chem. Revs., 1981, Vol. 39, 121, 131; 1975, 15, 321; 1990, 97, 313., V. Balzari and Carassiti, Photochemistry of Coordination Compounds, Academic Press., G.J. Ferraudi, Elements of Inorganic Photochemistry, Wiley-Eastern., K.K. Rohtagi-Mukherji, Fundamentals of Photochemistry, Wiley-Eastern., A. Gilbert and J. Baggott, Essentials of Molecular Photochemistry, Blackwell Scientific, Publication., ix. N.J. Turro, W.A. Benjamin, Molecular Photochemistry,, x. A.Cox and T.Camp, Introductory Photochemistry, McGraw-Hill., xi. R.P. Kundall and A. Gilbert, Photochemistry, Thomson Nelson., xii. J.Coxon and B. Halton, Organic Photochemistry, Cambridge University Press., , SEMESTER IV Paper IV, (Elective Paper Inorganic chemistry), 1. Subject Code : CHPG40I(d), Course Title: M.Sc., 2. Subject Area : Environmental Chemistry -4, 3. Course Hour, Lecture : L 48, T:10, P:60, Page 33 of 48

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4., 5., 6., 7., 8., , Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of eco-system and relevance of chemistry in nature, Objective of Course : Student should have knowledge of,  Environmental terminology and nomenclature.,  Chemical reaction of atmosphere and hydrosphere.,  Air and water pollution.,  Chemical toxicology, 9. Details of Course :, S.No., , 1, , 2, , 3, , 4, , 5, , 6, , Contents, , Contact, Hours/, Lectures, Introduction to Environmental Chemistry :Concept and scope 8 Lectures, of environmental chemistry.Environmental terminology and, nomenclatures. Environmental segments. The natural cycles of, environment (Hydrological, Oxygen, Nitrogen)., Atmosphere: Regions of the atmosphere, reactions in atmospheric 8 Lectures, chemistry, Earth’s radiation balance, particles, ion and radicals in, the atmosphere. Chemistry of ozone layer., Hydrosphere : Complexation in natural water and waste-water. 8 Lectures, Micro-organism in aquatic chemical reactions. Eutrophication., Microbiology mediated redox reactions, Lithosphere: Inorganic and organic components in soil, acid-base 8 Lectures, and ion-exchange reactions in soil, micro and macro nutrients,, nitrogen pathways and NPK in soil., Chemical Toxicology : Toxic chemicals in the environments. 8 Lectures, Impact of toxic chemicals on enzymes. Biochemical effects of, arsenic, cadmium, lead, mercury, carbon monoxide, nitrogen, oxides andsulphur oxides., Air Pollution and Water Pollution : Particulates, aerosols, SOx, 8 Lectures, NOx, COx and hydrocarbon. Photochemical smog, air-quality, standards., Water-quality parameters and standards: physical and chemical, parameters (colour, odour, taste and turbidity). Dissolved oxygen:, BOD, COD. Total organic carbon,nitrogen,sulfur,phosphorus and, chlorine. Chemical speciation (Pb, As, Hg)., , Books Recommended :, i., ii., , Neno Chemistry, Geoffrey A. Ozin, and Andre Arsentte RSC Publishing., Environmental Chemistry A.K. Day, New Age., , SEMESTER IV Paper V, (Elective Paper Organic chemistry), Page 34 of 48

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1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40O(a), Course Title: M.Sc., Subject Area : Organic Synthesis-4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of oxidation, redaxation and properties of C-C bonds., Objective of Course : Students should have the knowledge of,  Oxidation and reduction process.,  Organo metallic regents and ring synthesis.,  C-C Disconnection one and two group.,  Metallocenes, 9. Details of Course :, S.No., , 1, , 2, , 3, , 4, , Contents, , Contact, Hours/, Lectures, Organometallic Reagents : Principle, preparations, properties 5 Lectures, and applications of the following in organic synthesis:, Group I and II metal organic compounds, Li, Hg and Zn compounds., Transition metals: Pd, Ni, Fe, Ti, Cu, Rh and Cr compounds;, Other elements ;S, Si and B compounds, Oxidation: Introductino. Different oxidative processes., 10, Hydrocarbons-alkenes, aromatic rings, saturated C-H groups Lectures, (activated &unactivated)., Alcohols, diols, aldehydes, ketones, ketals and carbosylic acids., Amines, hydrazines and sulphides., Oxidation with ruthenium tetraoxide, iodobenzenediacetate and, thallium (III) nitrate., Reduction: Introduction, Different reductive process., Hydrocarbons-alkanes, alkenes, alkynes and aromatic rings., Carbonyl compounds-aldehydes, ketones, acids and their, derivatives., Epoxides, Nitro, nitroso, azo and oxime groups. Hydrogenolysis., Metallocenes, Nonbenzenoid Aromatics and Polycyclic 5 Lectures, Aromatic Compounds :General considerations, synthesis and, reactions of some representative compounds., Disconnection Approach, One group C-C Disconnections and 15, Two Group C-C Disconnections An introduction to synthons Lectures, and synthetic equivalents, disconnection approach, functional, group interconversions, the importance of the order of events in, organic synthesis, one group C-X and two group C-X, disconnections, chemoselectivity, reversal of polarity, cyclisation, reactions and amine synthesis. One group and two group C-C, Page 35 of 48

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disconnections., Alcohols and carbonyl compounds, regioselectivity, Alkene, synthesis, use of acetylenes and aliphatic nitro compounds in, organic synthesis., Diels-Alder reaction, 1,3-difunctionalised compounds, βunsaturated carbonyl compounds, control in carbonyl, condensations. Micheal addition and Robinson annelation, Protecting Group: Principle of protection of alcohol, amine, 5 Lectures, carbonyl and carboxyl groups., Ring Synthesis: Saturated hetercycles, synthesis of 3-,4-,5- and 6- 8 Lectures, membered rings, aromatic heterocycles in organic synthesis., , 5, 6, , BOOKS SUGGESTED, i., ii., iii., , H.O. House, W.A. Benjamin, Modern Synthetic Reaction,, , W. Carruthers, Some Modern Methods of Organic Synthesis. Cambridges Univ. Press., J. March, Advanced Organic Chemistry, Reactions Mechanisms and Structure. John, Wiley., iv., R.O.C. Norman an J.M. Coxon, Principles of Organic synthesis, Blackie Academic &, Professional., v., F.A. Carey and R.J. Sundberg,Advanced Organic Chemistry Part B, Plenum Press., vi., Rodd’s Chemistry of Carbon Compounds, Ed. S. Coffey, Elsevier., vii. S Warren, Designing Organic Synthesis, Wiley., viii. J. Fuhrhop and G. Penzillin,Organic Synthesis- Concept, Methods and Starting, Materials Verlage VCH., ix., W.A.Benjamin, Modern Synthetic Reactions, H.O. House,., , SEMESTER IV Paper VI, (Elective Paper Organic chemistry), 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40O(b), Course Title: M.Sc., Subject Area : Chemistry of Natural Products and Heterocyclic Compounds-4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of organic compounds present in natural products, Objective of Course : Students should have the knowledge of,  Classification, nomenclature of Alkaloids, terpenoids and steroids,  Occurrence and general aspects of Pigments/ porphyrins and PGE2,  Heterocyclics three and four membered rings.,  Spectroscopic techniques for elucidation of natural products, 9. Details of Course :, S.No., , Contents, , Contact, Hours/, Page 36 of 48

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benzofurans and benzothiophenes., (c) Six-Membered Hetercycles with Two or More, HeteroatomsSynthesis and reactions of pyrylium salts and, pyrones and their comparison with pyridinium&thiopyrylium, salts., Synthesis and reactions of benzopyrylium salts and coumarins., Synthesis and reacitons of diazines, triazines, tetrezines and, thiazines., Books Recommended, i. I.L. Finar Vol. I & II, ELBS., ii. Stereoselective Synthesis: A Practical Approach, M. Norgradi, VCH., iii. Rodd’s Chemistry of carbon Compounds, Ed. S. Coffey, Elsevir., iv. Chemistry, Biological and Pharmalogical Properties of Medicinal Plants from the, Americans, Ed. Kurt Hostettmann, M.P. Gupta and A. Marton, Harwood Academic, Publishers., v. Introduction to Flavonoids, B.A. Bhom, Harwood Academic Publishers., vi. New Trends in Natural Product Chemistry, Attu-ur-Rahman and M.I. Choudhary,, Harwood Academic Publishers., vii. Insecticides of Natural Origin, Suk Dev, Harwood Academic Publishers., viii., Heterocyclic Chemistry Vol. 1-3, R.R. Gupta, M. Kumar and V. Gupta,, Springer Verlag., ix. Chemistry of Heterocycles, T. Eicher and S. Hauptmann, Thieme., x. Contemporary Heterocyclic Chemistry, G.R. Newkome and W.W. Paudler, WileyInter Science., xi. An Introduction to the Heterocyclic Compounds, R.M. Acheson, John Wiley., xii. Comprehensive Heterocyclic Chemistry, A.R. Katritzky and C.W. Rees, eds., Pergamon press., xiii., Chemistry of Natural Products: A unified Approach, N.R. Krishnaswamy,, Universities Press, Hyderabad., , SEMESTER IV Paper VII, (Elective Paper Organic chemistry), 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40O(c), Course Title: M.Sc., Subject Area : Medicinal Chemistry-4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : General knowledge of diseases and class of medicine., Objective of Course : Students should have the knowledge of,  Drug design,  Introduction to drug absorption,  Pharmaco Kinetic parameters, Page 38 of 48

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 Different types of drugs, 9. Details of Course :, S.No., , 1, , 2, , 3, , 4, , 5, , Contents, , Contact, Hours/, Lectures, Drug Design : Development of new drugs, procedures followed 8 Lectures, in drug design, concepts of lead compound and lead modification,, concepts of prodrugs and soft drug, structure-activity relationship, (SAR), factors affecting bioactivity. Theories of drug activity:, general discussion. Quantitative structure activity relationship., History and development of QSAR. Concepts of drug receptors., Elementary treatment of drug receptor interactions. Physicochemical parameters: Lipophilicity, partition coefficient, electronic, ionization constants, steric, Shelton and surface activity, parameters and redox potentials. Free-Wilson analysis, Hansch, analysis, relationships between Free-Wilson and Hansch analysis., LD-50, ED-50 (Mathematical derivations of equations excluded)., Pharmacokinetics & Pharmacodynamics : Introduction to drug 8 Lectures, absorption, disposition, elimination using pharmacokinetics,, important pharmacokinetic parameters in defining drug disposition, and in therapeutics. Mention of uses of pharmacokinetics in drug, development process. Introduction, elementary treatment of, enzyme stimulation, enzyme inhibition, sulphonamides, membrane, active drugs, drug metabolism, xenobiotics, biotransformation,, significance of drug metabolism in medicinal chemistry., Antineoplastic Agents: Introduction, cancer chemotherapy, 8 Lectures, special problems, role of alkylating agents and antimetabolites in, treatment of cancer. Mention of carcinolytic antibiotic and mitotic, inhibitors., Synthesis of mechlorethamine, cyclophosphamide, melaphalan,, uracil, mustards and 6- mercaptopurine. Recent development in, cancer chemotherapy. Hormone and natural products., Cardiovascular Drugs: Introduction, cardiovascular diseases, 8 Lectures, drug inhibitors of peripheral sympathetic function, central, intervention of cardiovascular output., Direct acting arteriolar dilators., Synthesis of amyl nitrate, sorbitrate ,verapamil, atenolol., Local Anti-infective Drugs and Antibiotics, : Introduction 8 Lectures, and general mode of action. Syntehsis of sulphonamides,, furzolidone, nalidixic acid, ciprofloxacin, norfloxacin, dapsone,, amino salicylic acid, isoniazid, ethionamide, ethambutal,, fluconazole, econozole, griseofulvin, chloroquin and primaquin., Cell wall biosynthesis, inhibitors, β-lactam rings, antibiotics, inhibiting protein synthesis. Synthesis of penicillin G, penicillin V,, ampicillin,, amoxicillin,, chloramphenicol,, cephalosporin,, tetracycline and streptomycin., Page 39 of 48

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6, , Psychoactive Drugs-The Chemotherapy of Mind :Inroduction,, 8 Lectures, neurotransmitters, CNS depressants, general anaesthetics, mode of, action, of, hypnotics,, sedatives,, anti-anxiety, drugs,, benzodiazepines, buspirone, neurochemistry of mental diseases., Antipsychotic, drugs –the neuroleptics, antidepressants,, butyrophenones,, serendipity, and, drug, development,, stereochemical aspects of psychotropic drugs., Synthesis of diazepam, oxazepam, chlorazepam, alprazolam,, phenytoin, ethosuximide, trimethadione, barbiturates, thiopental, sodium, glutethimide., , Books Suggested, i., Introduction to Medicinal Chemistry, A. Gringuage, Wiley-VCH, ii. Wilson and Gisvold’s Text –Book of Organic Medicinal and Pharmaceutical, Chemistry, Ed Robert F. Dorge., iii. An introduction to Drug Design, S.S. Pandeya and U.R. Diiock, New Age International., iv. Burger’s Medicinal Chemistry and Drug Discovery, Vol.- 1 (Chapter 9 an Ch-14), Ed., M.E. Wolf, John Wiley., v. Goodman and Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill., vi. The Organic Chemistry of Drug Design and Drug Action, R.B. Silverman, Academic, Press., vii. Strategies for Organic Synthesis and Design, D. Lednicer, John Wiley., , SEMESTER IV Paper VIII, (Elective Paper Physical chemistry), 1., 2., 3., 4., 5., 6., 7., , Subject Code : CHPG40P(a), Course Title: M.Sc., Subject Area : Physical organic and Quantum Chemistry -4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Fundamental knowledge of characteristics of Atoms and, molecules, 8. Objective of Course : Students should have the knowledge of,  Angular momentum and eigen functions.,  Concept of M O and VB Theory,  Schrödinger equation to Harmonic oscillator,  Huckele molecular orbital, 9. Details of Course :, S.No., , Contents, , Contact, Hours/, Lectures, , Page 40 of 48

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1, , 2, , 3, , 4, , Quantum Chemistry : Plank’s quantum theory, wave- particle, duality, uncertainty principle, operators and commutation, relations, degeneracy, applications of Schrodinger’s wave equation, to harmonic oscillator, rigid rotator and hydrogen atom, angular, momentum including spin coupling of angular momentum and, spin-orbit coupling., Ordinary angular momentum, generalized angular momentum,, eigen functions for angular momentum, eigen values of angular, momentum, operator using ladder operators, addition of angular, momentum spins, antisymmetry and Pauli ‘s exclusion principle., Concepts in Molecular Orbital (MO) and Valence Bond (VB), Theory : Introduction to Hückle Molecular Orbital (MO) method, as means to explain modern theoretical methods, advanced, techniques in PMO and FMO theory, molecular mechanics, semi, empirical methods., Quantitative MO theory – Hückle Molecular Orbital (HMO), methods, qualitative MO theory-ionization potential, electron, affinities, MO energy levels, orbital symmetry, orbital interaction, diagrams, MO of simple organic systems., Valence Bond (VB) configuration mixing diagrams, relationship, between VB configuration mixing and resonance theory, reaction, profiles, potential energy diagrams, curve-crossing model nature, of activation barrier in chemical reaction., Kinetic Isotope Effect: Theory of isotope effects, primary and, secondary kinetic isotope effects, heavy atom Isotope effects., tunneling effect, solvent effects., Supramolecular Chemistry: General discussion and its, importance., , 16, Lectures, , 16, Lectures, , 8 Lectures, , 8 Lectures, , Books Suggested, i., ii., iii., iv., v., vi., vii., viii., ix., x., xi., xii., xiii., xiv., xv., , Molecular Mechanics, Burkert and NL Allinger, ACS Mongograph., Organic Chemists’ Book of Orbitals, L. Salem and WL Jorgensen, Academic Press, Mechanism and Theory in Organic Chemistry, TH Lowry and KC Rechardson, Harper, and Row, Introduction to Theoretical Organic Chemistry and Molecular Modeling,, W.B. Smith, VCH, Weinhelm, Physical Organic Chemistry, N.S Isaacs, ELBS/Longman, Supramolecular Chemistry, Concepts and Perspectives, J.M. Lehn. VCH, The Physical Basis of Organic Chemistry, H Maskill, OxfordUniversity Press., RS Molecular Mechanics, 3rd Ed., PW Atkins, Friedman, OxfordUniversity Press, (1997), Quantum Chemistry 5th Ed., Ira N Levine Prentice-Hall Inc.: New Jersey, Quantum Chemistry, J.P. Lowe & Peterson, Academic Press, Introduction to Quantum Chemistry, A. K. Chandra, Tata McGraw Hill, Coulson’s valence, R McWeeny,ELBS, Micelles, Theoretical and Applied Aspects, V.Moroi, Plenum., Modern Quantum Chemistry, NS Ostlund and A Szabo, McGraw Hill, Page 41 of 48

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xvi., , Methods of Molecular Quantum Mechanics, R McWeeny and BT Sutcliffe, Academic, Press., Density Functional Theory of Atoms and Molecules, RG Parr and W Yang, Oxford., Exploring Chemistry with Electron Structure Methods, JB Foresman and E Frish,, GoussianInc, Semi-empirical MO Theory, J Pople and DL Beveridge, , xvii., xviii., xix., , SEMESTER IV Paper IX, (Elective Paper Physical chemistry), 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40P(b), Course Title: M.Sc., Subject Area : Advanced Chemical Dynamics, Thermodynamics-4, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Knowledge of thermodynamics and kinetic processes, Objective of Course : Students should have the knowledge of,  Influence of solvent on reactions,  Types of techniques used in fast kinetics,  Theories of reaction rates,  Thermodynamic probability and statistical thermodynamics,  Partial molar quantities., 9. Details of Course :, S.No., , 1, , 2, , Contents, , Contact, Hours/, Lectures, A. Advanced Chemical Dynamics : Theories of reaction rates: 12, Partition functions (transtational, vibrational and rotational) for Lectures, diatomic molecules and application to rate processes, statistical, mechanics of chemical equilibrium, theory of absolute reaction, rates, thermodynamical formulation of reactions rates, theories of, unimolecular reactions: Lindemann’s theory, Hinshelwood’s, treatment, RRK treatment, Slater’s theory (no derivation), RiceRamsperger-Kassel-Marcus (RRKM) theory (no derivation),, general treatment of chain reactions, branching chains, explosive, reactions between hydrogen and oxygen, oxidation of, hydracarbons, polymerization reactions (molecular and free, radical), oscillatory reactions, kinetic isotope effect., Kinetics in Solution : Influence of solvent reactions between 6 Lectures, ions, reactions between ions and molecules, reactions involving, dipoles, influence of ionic strength, primary and secondary salt, effects, homogeneous and heterogeneous catalysis, absolute rate, theory of heterogeneous reactions.Enzyme Catalysis: MichaelisMenton mechanism , single and double intermediates, general, Page 42 of 48

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3, , 4, , 5, , methods for working out the kinetics of complex enzymatic, reactions., Fast Chemical Reactions - : Study of kinetics by stopped flow, techniques, relaxation methods, flash photolysis and magnetic, resonance methods and temperature jump method., B. Advanced Thermodynamics, Statistical Thermodynamics :Thermodynamic probability and, entropy , Maxwell-Boltzmann, Bose-Einstein and Fermi-Dirac, statistics. Partition function: Translational, rotational, vibrational, and electronic partition functions for diatomic molecules,, calculations of thermodynamic parameters and, Chemical equilibrium: Free energy and entropy of mixing,, partial molar quantities, Gibbs-Duhem equation, equilibrium, constant, temperature-dependence of equilibrium constant,, chemical potential and its use in heterogeneous equilibrium,, fugacity, its significance and determination, ideal solutions and, their properties, Duhem-Margules equation and its applicability., Dilute solutions: Lowering of melting point and elevation of, boiling point, Gibb’s-Helmholtz equation and its uses, Nernst heat, theorem, third law of thermodynamics, entropy determination, from the third law of thermodynamics., , 6 Lectures, , 12, Lectures, , 12, Lectures, , Books Suggested, i. Statistical Mechanics: Principles and Selected Application, TL Hill, Dover, Publications Inc.: New York, ii. Chemical Kinetics, KJ Laidler, Mcgraw Hill, iii. Kinetics and Mechanism of Chemical Transformations, J Rajaraman and J, Kuriacose, McMillan, iv. Computer Simulations of Liquids, MP Allen and DJ Tildesley, Oxford Science, Publications: Oxford, v. Statistical Physics Vol.5, Part 1, 3rd Ed., LD Landau and IMLifshitz, Pergamon, Press, vi. Stochastic Processes in Physics & Chemistry 2nd Ed., NG vanKampen, Elsevier, Science, vii. Reaction Kinetics, MJ Pilling and PW Seakins, Oxford Press, viii. Thermodynamics for Chemists, S. Glasstone, ix. Advanced Thermodynamics, RP Rastogi, x. Electrochemistry by S. Glasstone, xi. Electrochemical Methods: Fundamentals and Applications. 2nd Ed., Bard, AJ,, Faulkner, L.R. John. Wiley & Sons: New York, xii. Principle of Electrochemistry, J Koryta, J Dvorak, L. Kavan, John Wiley & Sons:, NY, xiii. Modern Electrochemistry, Vol I & II, JOM Bockris and AKN Readdy, Plenum., xiv. Modern Electrochemistry, Vol I & II, JOM Bockris and AKN Readdy, Plenum, , Page 43 of 48

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SEMESTER IV Paper X, (Elective Paper Physical chemistry), 1., 2., 3., 4., 5., 6., 7., 8., , Subject Code : CHPG40P(c), Course Title: M.Sc., Subject Area : Advanced Photochemistry and Nuclear Chemistry, Course Hour, Lecture : L 48, T:10, P:60, Exam Time, Theory:3 hours, Practical : 8 hours, Relative weightage Theory: 80, Practical :20, Credits :, Pre requisite : Fundamental knowledge of Photon properties, Objective of Course : Students should have the knowledge of,  Nuclear reactions.,  Radioactive transition,  Types of excitation,  Transfer of excitation energy,  Rates of photochemical reactions, 9. Details of Course :, S.No., , 1, , 2, , 3, , 4, , 5, , Contents, , Contact, Hours/, Lectures, Photochemical, Reactions:Interaction, of, electromagnetic 8 Lectures, radiation with matter, types of excitations, fate of excited, molecule, quantum yield, transfer of excitation energy,, actinometry., 8 Lectures, Miscellaneous Photochemical Reactions:, Singlet molecular oxygen reactions, photochemical formation of, smog and photodegradation of polymers., Determination of Reaction Mechanism: Classification,, rate 8 Lectures, constants and life times of reactive energy states, determination of, rate constants, effect of light intensity on the rate of photochemical, reactions., Molecular Photochemistry: Transitions, between, states 8 Lectures, (Chemical, classical and quantum dynamics, vibronic states)., Potential energy surfaces; transitions between potential energy, surfaces, radiative transitions. A classical model of radiative, transitions. The absorption and emission of light-state mixing,, spin-orbit coupling and spin forbidden radiative transitions,, absorption complexes, fluorescence, phosphorescence and, chemiluminiscence., Advanced Nuclear Chemistry : Radioactive equlibrium , nuclear 16, reaction, Q value cross section, types of reaction. Theory of Lectures, Nuclear, forces., Radioactive, decay,, alpha,, beta,, gamma,nuclearreactions;charecteristics and similarities with, chemical reactions , threshold and cross section,nuclear reaction, due to neutron, proton, deutron and gamma irradiation,, Page 44 of 48

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Nuclearfission,fission cross section, chain fission and resonance, capture. Fission products and fission yields, mass and charge, distribution in fission and spallation reaction, nuclear reactor., Nuclear fission and stellar energy, Books Suggested, i., Modem Molecular Photochemistry, NJ Turro, University Science Books, ii. Essentials of Molecular Photochemistry, A Gilbert, J Baggot, Blackwell Scientific, iii. Fundamentals of Photochemistry, K.K. Rohtagi-Mukharji, Wiley- Eastern., iv. Molecular Photochemistry, NJ Turro, W.A. Benjamin., v. Introductory Photochemistry, A Cox and T. Champ, McGraw-Hill., vi. Photochemistry, R.P. Kundall and A. Gilbert, Thomson Nelson., vii. Organic Photochemistry, J. Coxon and B. Halton, CambridgeUniversity Press., viii. Modern molecular photochemistry, NJ Turro, University Science Books., ix. Nuclear chemistry by Arnikar, x. Advanced Physical Chemistry, D. N. Bajpai, S. Chand and Co., xi. Modern Physical Chemistry, Kundu and Jain, S. Chand and Co., , Organic Laboratory Course, , 08 hrs, I- Qualitative Analysis, 24, Separation, purification and identification of the components of a mixture of three, organic compounds (three solids or two liquids and one solid, two solids and one liquid),, using TLC for checking the purity of the separated compounds, chemical analysis, IR,, PMR and Mass Spectral data (sets of spectra may be provided to Students for, characterization of components)., II- Extraction of Organic Compounds from Natural Sources (Minimum of any two of, the following exercises are compulsory), 18, I) Isolation of caffeine from tea leaves., II) Isolation of casein from milk (the students are required to try some typical colour, reactions of proteins)., III) Isolation of lactose from milk (purity of sugar should be checked by TLC, PC and Rf, value reported)., IV) Isolation of nicotine dipicrate from tobacco., V) Isolation of cinconine from cinchona bark., VI) Isolation of piperine from black pepper., VII) Isolation of lycopene from tomatoes., VIII) Isolation of β-carotene from carrots., IX) Isolation of oleic acid from olive oil (involving the preparation complex with urea and, separation of linoleic acid)., X) Isolation of eugenol from cloves., XI) Isolation of limonene from citrus fruits., III- Spectroscopy, 18, Identification of organic compounds by the analysis of the spectral data (UV, IR, PMR,, CMR & MS), Note: Record(including test) 15; attendance 10;viva 15, Page 45 of 48

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Books suggested, i. Introduction, to, Organic, Laboratory, Techniques, (Third, Edition),DLPavia,GMLampman& GS Kriz, Saunders College Publishing, Phildelphia,, New York., ii. Operational organic chemistry, A Laboratory Course, Second Edition, JW Lehman., Allyn&Bacon, Inc.Boston., iii. Microscale Organic experiments KL Willianson, DC Heath & Co Le. Xington., iv. Laboratory Manual of Organic Chemistry, RK Bansal, New age International, Delhi, v. Vogel’s Text book of quantitative Analysis, (revised), J.Bassett, R.C. Denney, G.H., Jeffery and J. Mendham, ELBS, vi. Synthesis and Characterization of inorganic Compounds, W.L. Jolly, Prentice Hall, vii. Experiments and Techniques in Organic Chemistry, D. Pasto, C. Johnson and M., Miller, Prentice Hall, viii. Macroascale and Microscale Organic Experiments, K.L. Williamson and D.C. Heath., ix. Systematic Qualitative Organic Analysis, H. Middleton and Adward Arnold., x. Handbook of Organic Analysis, Qualitative and Quantitative, H. Clark and Adward, Arnold, xi. Vogel’s Textbook of Practical Organic Chemistry, A.R. Tatchell, John Wiley., xii. Practical Physical Chemistry. A.M. James and F.E. Prichard, Longman., xiii. Findley’s Practical Physical Chemistry, B.P. Levitt Longman., xiv. Experimental Physical Chemistry, R.C. Das and B. Behera, Tata McGraw Hill., , Physical Chemistry Lab course, , 08 hrs, 1. Study of complex formation by the following methods and determination of stability, constant wherever practicable:, (a) Cryoscopy, (b) Electrical Methods, (c) E.M.F., 2. Determination of transport number., 3. Determination of liquid junction potential., 4. Determination of the charge on colloidal particle., 5. Determination of λ(max) of compounds and verification of Beer’s law., 6. Validity of Langmuir’s adsorption isotherm., 7. Determination of partial molar volume of solute., 8. Determination of the following thermodynamic parameters of a reaction, (a) Enthalpy of activation., (b) Entropy of activation., (c) Free energy change., (d) Equilibrium constant., (e) Frequency factor, 9. Conductrometric determination of the equivalent conductivity at infinite dilution of a, strong electrolyte., 10. Determination of the dissociation constant of a weak acid by conductivity method., 11. Conductrometric determination of the equivalent conductivity at infinite dilution of a, weak electrolyte., 12. Validity of Ostwald’s dilution law., Page 46 of 48

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13. Determination of the degree of dissociation/ association conductrometrically., 14. Determination of the formula of silver ammonia complex & copper ammonia complex., 15. Kinitetic Study of the primary salt effect, 16. Determination of the velocity constant, order of the reaction and energy of activation for, saponification of ethyl acetate by sodium hydroxide conductometrically., 17. Determination of pH by EMF., 18. Hydrolysis of the salts by cryoscopic method., 19. Determination of strengths of halides in a mixture potentiometrically., 20. Determination of the valency of mercurous ions potentiometrically., 21. Determination of the strength of strong and weak acids in a given mixture using a, potentiometer/pH meter., 22. Verification of the law of photo-chemical equivalence., Note: The candidates shall have to do a minimum of 10 experiments. Record(including, test) 15; attendance 10; viva 15, , Inorganic Chemistry Lab course, , 08 hrs, , 1., , Semimicro analysis of inorganic mixture for six radicals., 24, 2. Analysis of ores, alloys and inorganic substances by qualitative and quantitative, methods. 18, Or, Three component metal ion analysis (one volumetric and two gravimetric methods) 18, 3. Preparation, 18, Synthesis of selected inorganic compounds/ complexes and their characterization by, IR, electronic spectra (UV & Visible), NMR, Mossbauer, ESR and magnetic, susceptibility etc. measurements. Selection can be made from the following or any, other from the existed literature., (i) cis-and trans- isomers of [Co(en)2Cl2] Cl., J. Chem. Soc., 1960, 4369., (ii) Metal acetylacetonates: [Cr9acac)3]; Vanadylacetylacetonate, [Cu(acac)2. H2O, etc., Inorganic Synthesis, 1957, 5, 130; 1, 183., (iii) Ferrocene, J. Chem. Edu., 1996, 43, 73; 1976, 53, 730., (iv), Cr(II) complexes: [Cr (H2O)6] (NO3)3. 3H2O; [Cr(H2O)4 Cl2] Cl.2 H2O;, [Cr(en)3]Cl3, Inorg. Synth., 1972, 13, 184., (v), Tin(IV) iodine, Tin(IV) choride, Tin(II) iodine., Inorg. Synth., 1953,4,119., (vi), Mixed valence dinuclear complexes of manganese (III, IV)., (vii) Preparation of tripheny phosphine and its transition metal complexes., (viii) Reaction of Cr(III) with multidentate ligand, a kinetic experiment (visible, spectra of Cr-EDTA complex)., J. Am. Chem Soc., 1953,75,5670., (ix) Other new synthesis reported in literature., (x) Bromination of [Cr(acac)3]., J. Chem. Edu., 1986,63,90., Page 47 of 48

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(xi) Preparation of copper glycine complex- cis- and trans- bisglycinato copper (II)., J. Chem. Edu., 1982,59,1052., (xii) Relative stability of Tin(IV) and Pb(IV), preparation of ammonium, hexachlorostannate, (NH4)[SnCl6) and ammonium hexachoroplumbate; (NH4)2, [PbCl6]., Note: Record (including test) 15; attendance 10; viva 15, Note :For conducting Chemistry Practical Examination in Semester I, II and III only One, external examiner shall be appointed in each Semester. External examiners shall be, appointed from all the three specialization viz Inorganic, Organic and Physical in semester I,, II and III as per syllabus., PROJECT WORK, In the IV Semester the candidate shall have to do a Project. The topic of the project, shall be allotted to him/her by the Project Supervisor. The submission of the project, shall be mandatory for each candidate and he/she will have to submit the, project/dissertation not later than the date of his/her practical examination., , Prof. N.D. Kandpal, Convener, BOS Chemistry, Head, Department of Chemistry, Kumaun University, Nainital, , Page 48 of 48