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I.K. Gujral Punjab Technical University, M. Pharmacy-Pharmaceutics/Batch 2017, Course, Code, MPH203T, , Course Title, Computer Aided Drug, Delivery System, , Teaching, Load, L, P, 4, -, , Marks, Int., 25, , Ext., 75, , Exam, (hrs), Int. Ext., 1, 3, , Credits, 4, , Scope: This course is designed to impart knowledge and skills necessary for computer Applications, in pharmaceutical research and development who want to understand the application of computers, across the entire drug research and development process. Basic theoretical discussions of the, principles of more integrated and coherent use of computerized information (informatics) in the drug, development process are provided to help the students to clarify the concepts., Objectives: Upon completion of this course, it is expected that students will be able to understand, 1., 2., 3., 4., 5., 6., 7., 8., , History of Computers in Pharmaceutical Research and Development, Computational Modeling of Drug Disposition, Computers in Preclinical Development, Optimization Techniques in Pharmaceutical Formulation, Computers in Market Analysis, Computers in Clinical Development, Artificial Intelligence (AI) and Robotics, Computational fluid dynamics (CFD), , Module 01, , 12 Hours, , Computers in Pharmaceutical Research and Development,  A General Overview,  History of Computers in Pharmaceutical Research and Development, Statistical Modeling in Pharmaceutical Research and Development,  Descriptive versus Mechanistic Modeling, Statistical Parameters, Estimation, Confidence, Regions, Nonlinearity at the Optimum, Sensitivity Analysis, Optimal Design, Population, Modeling, Quality-by-Design in Pharmaceutical Development,  Introduction, ICH Q8 guideline, Regulatory and industry views on,  QbD, Scientifically based QbD - examples of application, Module 02, , 12 Hours, , Computational Modeling of Drug Disposition,  Introduction,  Modeling Techniques: Drug Absorption, Solubility, Intestinal Permeation, Drug Distribution,, Drug Excretion, Active Transport; P-gp, BCRP, Nucleoside Transporters, hPEPT1, ASBT,, OCT, OATP, BBB-Choline Transporter, , Page 25 of 33

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I.K. Gujral Punjab Technical University, M. Pharmacy-Pharmaceutics/Batch 2017, Module 03, 12 Hours, Computer-Aided Formulation Development,  Concept of optimization, optimization parameters, factorial design, optimization technology, and screening design, Computers in Pharmaceutical Formulation,  Development of pharmaceutical emulsions,  Microemulsion drug carriers,  Legal protection of innovative uses of computers in R&D,  The ethics of computing in pharmaceutical research,  Computers in market analysis, Module 04, , 12 Hours, , Computer-Aided Biopharmaceutical Characterization, Gastrointestinal Absorption Simulation,  Introduction, Theoretical background, Model construction, Parameter sensitivity analysis,, Virtual trial, Fed vs. fasted state, In vitro dissolution and in vitro- in vivo correlation, Biowaiver considerations, Computer Simulations in Pharmacokinetics and Pharmacodynamics,  Introduction, Computer Simulation,  Whole Organism, Isolated Tissues, Organs, Cell, Proteins and Genes, Computers in Clinical Development,  Clinical Data Collection and Management, Regulation of Computer Systems, Module 05, , 12 Hours, , Artificial Intelligence (AI), Robotics and Computational Fluid Dynamics,  General overview, Pharmaceutical Automation, Pharmaceutical applications,  Advantages and Disadvantages,  Current Challenges and Future Directions, Recommended Books (Latest editions), 1. Computer Applications in Pharmaceutical Research and Development, Sean Ekins, John, Wiley & Sons., 2. Computer-Aided Applications in Pharmaceutical Technology, Jelena Djuris, Woodhead, Publishing., 3. Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James. G.Boylan,, Marcel Dekker Inc, New York., , Page 26 of 33