Page 1 :
BUERGER’S DISEASE, Buerger’s disease…. Thromboangiitis obliterans, Inflammatory arteriopathy., Predominantly affects small and medium sized arteries., Changes are pathologically distinct from atherosclerosis., The lower extremity is predominantly affected., It Classically affects young male smoker., Leo Burger first discovered condition., Patient present with rest pain and tissue loss., Consider the diagnosis in any young patient with symptoms and sign of critical ischemia., Patient are young and mobile., Suspect Buerger’s disease in young male smokers with significant ischemia and, Preserved proximal pulse., The pathological features at a microscopic level involves an acute hypercellular, thrombosis causing arterial occlusion., Perivascular inflammation that can also affect veins., Patients with Buerger’s disease are not hypercoagulable., Normal arteries to knee level., Abrupt occlusion of tibial vessels with corkscrew collaterals feeding of the distal vessels., DIAGNOSTIC CRITERIA, Exclusion other cause, Tobacco use, Distal extremity disease(femoral pulses nearly always palpable), Young age of onset(<45 years), The presence of upper limb disease and phlebitis migrans strengthen diagnosis., OTHER FORM OF VASCULITIS, TAKAYASU ARTERITIS, Affect larger arteries such as aorta, Female predominant, 2nd and 3rd decade, GIANT CELL ARTERITIS, Temporal arteritis, Granulomatous vasculitis, Affect large and medium size arteries, Cranial vessels most commonly affected, Present with cranial ischemia(visual loss, jaw claudication and headache)